Over the past 30 years, Australia鈥檚 Tasmanian devil population has been afflicted with an infectious cancer that has pushed the species to near extinction. The marsupials are highly susceptible to devil facial tumor disease, which is almost always fatal to their species. The genomic interactions between the disease and its host correlate with how quickly a susceptible animal becomes infected after exposure to the pathogen.
Through DNA sequencing of the animals and their tumors, 国产短视频Assistant Professor of Integrative Biology Mark Margres and PhD student Dylan Gallinson have tracked the genomic interactions between the devils and the cancer. Their findings have been published in a coauthored paper, in the Proceedings of the National Academy of Sciences (PNAS).
鈥淎 big question in biology is the genetic basis for disease. The classic way to determine this is through genome studies and regression analysis that matches genes with disease risk,鈥� Margres said. 鈥淧reviously there hadn鈥檛 been a technique to study the interactions between both genomes.鈥�
Using a recently developed joint genome-wide association study, Margres and Gallinson assessed 960 genomes and 15 years of data on captured devils to track the co-evolution of the devils and the cancer.
鈥淥ur collaborators in Tasmania have been monitoring the spread of the disease and collecting tissue samples,鈥� Gallinson said. 鈥淲e sequenced the DNA of both the tumors and the devils to find the mutation that contributes to the manifestation of the disease.鈥�
Their findings can inform both epidemiological models that track infectious diseases and devil management strategies that focus on saving the endangered species.